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yirB [2019-02-01 12:43:32]
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yirB [2019-02-01 12:43:32]

anti-adaptor protein, inhibits [protein|87124945A1CBF7990856FBEB9EAD25096DAC0868|YjbH], responsible for stabilization of [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx] in response to cell wall stress
locus
BSU33029
pI
9.93
mw
6.60 kDa
protein length
54 aa Sequence Blast
gene length
165 bp Sequence Blast
function
control of [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx] proteolysis
product
anti-adaptor protein
essential
no
synonyms
yuzO
Outlinks
KEGGBsubCycUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.4|Additional proteins involved in proteolysis]

    • Gene

    Coordinates
    3,387,781 3,387,945

    The protein

    Catalyzed reaction/ biological activity

  • prevention of the [protein|87124945A1CBF7990856FBEB9EAD25096DAC0868|YjbH]-[protein|2C6386E9A63F410558D168798D077DF91590F454|Spx] interaction [Pubmed|21378193]

    • Structure

  • [PDB|5BRQ] (from B. licheniformis, 29% identity)

    • Expression and Regulation

    Operons

    genes
    [gene|5EC57A51EF2DC48070615653B7A3C1007CFEE01D|yirB]
    description
    [pubmed|30001325]

    regulatory mechanism

  • [protein|1D6C340264B8A75727E202AD2E37053091C94013|YuxN]: repression, [pubmed|30001325], in [regulon|1D6C340264B8A75727E202AD2E37053091C94013|YuxN regulon]
  • [protein|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR]: activation, CssR-P acts as anti-repressor [pubmed|30001325], in [regulon|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR regulon]

    • regulation

  • induced by vancomycin ([protein|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR]-P) [pubmed|30001325]
  • induced by cell wall stress ([protein|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR]) [pubmed|30001325]
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    Biological materials

    Mutant

  • BKE33029 ([gene|5EC57A51EF2DC48070615653B7A3C1007CFEE01D|yirB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33029 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTAGATTCACCCTTTC, downstream forward: _UP4_TAAAAAAATAGACTGCAAAA
  • BKK33029 ([gene|5EC57A51EF2DC48070615653B7A3C1007CFEE01D|yirB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33029 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTAGATTCACCCTTTC, downstream forward: _UP4_TAAAAAAATAGACTGCAAAA

    • References

    Reviews

  • 23375660

    • Research papers

  • 21378193,30001325